Computational PhD Intern, Clinical Science - Summer 2020

| Chicago
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Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

At a summer at Tempus, you will:

  • Apply skills and knowledge learned in the classroom to on-the-job experiences
  • Comprehensive, value-added project(s)
  • Have access to senior leadership and be involved in decision-making
  • Work in teams and with colleagues in a professional environment
  • Develop technical skills specific to your major
  • Provides opportunities for professional development by building relationships and learning about other parts of the business
  • End of summer presentation to the local management team

Duration and Timing
Tempus summer associates will spend ten weeks working in our Chicago headquarters. The program will commence in May/June and run through mid-August. 


Qualifications

  • Candidates must be enrolled in a post-grad degree program, preferably a doctoral program in Human Genetics, Cancer Genetics or Biological Sciences or a relevant quantitative discipline (eg bioinformatics, computational biology, statistical genetics, etc) 
  • Proficient in a scripting language, preferably R or Python
  • Previous experience working with large NGS data sets and producing robust, well-annotated and reproducible analysis code
  • Familiarity with human mutation databases, genome browsers and HGVS nomenclature
  • Oncology experience strongly preferred
  • Demonstrated attention to detail, excellent communication and writing skills

Responsibilities include:

  • Perform rigorous quantitative analysis of high dimensional molecular and clinical data
  • Utilize a variety of computational tools to analyze sequencing variants from NGS data
  • Help develop and validate novel computational tool(s) for clinical genomics platform 
  • Work independently and with other teammates in an interdisciplinary setting
  • Effectively communicate project updates and key findings in weekly progress meetings
  • End of summer presentation to clinical science leadership and other relevant teams

Proposed Project Description:

At Tempus, we have amassed the world’s largest library of clinical and molecular data and are committed to generating data-driven solutions to improve patient care. In this project, we aim to leverage and integrate our rich repository of DNA and RNA-seq data from our clinical oncology genomics platform in order to refine splice variant prediction and prioritization. Specifically, this project aims to detect splicing variants at natural and cryptic splice sites in DNA sequencing data from tumors using well-established and novel in silico splice variant prediction algorithms. Splice variants will be validated using in-house RNA-Seq data and compared against published pan-cancer databases of splice variants. Follow-up analyses will assess the impact of novel validated splice variants on variant classification for clinical reporting purposes as well identify novel candidates for potential biomarker discovery. 

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Technology we use

  • Engineering
  • Product
  • Sales & Marketing
    • JavascriptLanguages
    • PythonLanguages
    • SqlLanguages
    • AWSLanguages
    • ReactLibraries
    • ReduxLibraries
    • Node.jsFrameworks
    • Microsoft SQL ServerDatabases
    • MySQLDatabases
    • PostgreSQLDatabases
    • SQLiteDatabases
    • tableuAnalytics
    • JIRAManagement
    • SalesforceCRM

Location

600 WEST CHICAGO AVENUE, Chicago, IL 60654

An Insider's view of Tempus

What makes someone successful on your team?

We value creativity in ideation, autonomy in execution, and a healthy tendency to always question the status quo.

Ash

Lead Data Scientist

What are Tempus Perks + Benefits

Culture
Volunteer in local community
Friends outside of work
Eat lunch together
Daily stand up
Open door policy
Team owned deliverables
Team based strategic planning
Group brainstorming sessions
Pair programming
Open office floor plan
Health Insurance & Wellness Benefits
Flexible Spending Account (FSA)
Dental Benefits
Vision Benefits
Health Insurance Benefits
Life Insurance
Wellness Programs
Onsite Gym
Retirement & Stock Options Benefits
401(K)
Company Equity
Child Care & Parental Leave Benefits
Generous Parental Leave
Vacation & Time Off Benefits
Unlimited Vacation Policy
Generous PTO
Paid Volunteer Time
Paid Holidays
Perks & Discounts
Beer on Tap
Casual Dress
Commuter Benefits
Company Outings
Stocked Kitchen
Some Meals Provided
Happy Hours
Relocation Assistance
Fitness Subsidies
Professional Development Benefits
Diversity Program
Lunch and learns
Promote from within
Time allotted for learning
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