Leads clinical science strategy and execution for CAR T-cell therapy trials in autoimmune diseases. Oversees trial design, interpretation, clinical development plans, protocols, regulatory submissions, publications, and health authority interactions. Partners with cross-functional teams, investigators, key opinion leaders, and strategic partners while ensuring GCP and regulatory compliance. Represents clinical development externally, mentors clinical scientists, and supports organizational capability building.
Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases. Guided by our core values, Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome, we are committed to transforming the future of treatment for autoimmune disease. Join us at the forefront of cell therapy innovation and help redefine what’s possible.
Title: Senior Director, Clinical Science
Location: Remote or Hybrid
Reports To: SVP, Clinical Development & Medical Affairs
Responsibilities
- Serve as the senior clinical scientist for CAR T-cell therapy clinical trials in autoimmune disease indications, in partnership with internal and external cross-functional teams
- Partner with clinical operations, biometrics, regulatory, and commercial teams to ensure alignment on strategy and execution
- Lead design, execution, and interpretation of clinical trials across assigned program
- Provide scientific input into clinical development plans, study protocols, investigator brochures, and regulatory submissions.
- Participate in the development of clinical trial documents including protocols, ICFs, clinical development plans, and publications.
- Lead the development of clinical sections of regulatory documents including the IB, safety updates, clinical study reports, and responses to Health Authorities in collaboration with the study physician.
- Represent Clinical Development for the assigned program with cross-functional leaders
- Represent Clinical Development for the assigned program with key opinion leaders and strategic partners to inform clinical and scientific strategy
- Represent Clinical Development for the study team in high-impact external settings (advisory boards, regulatory meetings, major congresses), as appropriate
- Contribute to external scientific narrative and positioning through publications, presentations, and collaborations.
- Ensure compliance with GCP, corporate policies, and applicable local regulations.
- Lead, mentor, and develop high-performing clinical scientists and other staff
- Foster a culture of innovation, accountability, and scientific rigor.
- Contribute to Clinical Development organizational design and capability building to support future pipeline growth and complexity.
Qualifications
- Advanced degree (Ph.D., Pharm.D., M.D., or equivalent) in a scientific or life sciences discipline required
- 10+ years of progressive experience in drug development, including significant experience across multiple programs, including late-stage global clinical trials
- Demonstrated success in developing and executing clinical strategies at a program level
- Experience in late-stage clinical trials required; experience with BLA/NDA filing preferred
- Experience in cell and gene therapy, immunology, autoimmune disease, or related fields preferred
- Deep understanding of global regulatory frameworks and clinical development pathways required
- Strong operational acumen with excellence and efficiency
- Exceptional communication and management skills
- Ability to operate independently and effectively in a fast-paced, highly dynamic environment
- Ability to travel up to 15% of the time
The national salary range for this position is $260K to $290K USD annually. This salary range is an estimate of what we reasonably expect to pay for this position, and the actual salary may vary based on factors including experience, education, geographic location, internal equity, and market data. This position is also eligible for annual bonus, equity, benefits, and participation in the Company’s stock plan.
Similar Jobs
Artificial Intelligence • Cloud • HR Tech • Information Technology • Productivity • Software • Automation
Lead complex, cross-functional Data and Analytics programs spanning Product, Engineering, Marketing, Sales, and Customer Success. Coordinate executive governance, establish business metrics, deliver leadership insights, and drive product reviews and strategy cadences. Own go-to-market readiness, resolve critical-path issues, govern NPI processes, and manage Product Advisory Council activities. Apply AI to improve program efficiency, decision-making, communication, and risk management.
Top Skills:
Artificial Intelligence (Ai)SaaSServicenow
.jpg)
Fintech • Insurance • Payments • Social Impact • Financial Services
Processes escrow disbursements for mortgage and consumer loans, including taxes, hazard insurance, and PMI. Reviews tax and escrow reports, reconciles general ledger accounts, performs loan setup quality checks, manages insurance and service-provider relationships, maintains servicing records, analyzes operational reports, and responds to client inquiries. The role also supports issue resolution, reporting, and departmental projects while maintaining accuracy and service quality.
Top Skills:
CorelogicExcelMicrosoft OutlookMicrosoft Word
.png)
Logistics • Marketing Tech • Software
Generates awareness and qualified interest through cold calls, email, and social outreach. The BDR develops tailored multichannel prospecting strategies, communicates Lob’s product benefits, schedules meetings for Account Executives, supports initial engagements, and accurately tracks activities. This role also helps establish and improve the company’s outbound go-to-market motion while prioritizing accounts and continuously optimizing outreach processes.
What you need to know about the Chicago Tech Scene
With vibrant neighborhoods, great food and more affordable housing than either coast, Chicago might be the most liveable major tech hub. It is the birthplace of modern commodities and futures trading, a national hub for logistics and commerce, and home to the American Medical Association and the American Bar Association. This diverse blend of industry influences has helped Chicago emerge as a major player in verticals like fintech, biotechnology, legal tech, e-commerce and logistics technology. It’s also a major hiring center for tech companies on both coasts.
Key Facts About Chicago Tech
- Number of Tech Workers: 245,800; 5.2% of overall workforce (2024 CompTIA survey)
- Major Tech Employers: McDonald’s, John Deere, Boeing, Morningstar
- Key Industries: Artificial intelligence, biotechnology, fintech, software, logistics technology
- Funding Landscape: $2.5 billion in venture capital funding in 2024 (Pitchbook)
- Notable Investors: Pritzker Group Venture Capital, Arch Venture Partners, MATH Venture Partners, Jump Capital, Hyde Park Venture Partners
- Research Centers and Universities: Northwestern University, University of Chicago, University of Illinois Urbana-Champaign, Illinois Institute of Technology, Argonne National Laboratory, Fermi National Accelerator Laboratory
