Top Remote Senior Full-Stack Engineer Jobs in Chicago, IL

Lead backend TypeScript development and maintain services used by ~5M users. Contribute to full-stack features, code reviews, architecture discussions, mentor engineers, and collaborate with PM/design to build React-based web and mobile experiences.

Lead design and implementation of cloud-first, AI-integrated full-stack applications on GCP. Drive rapid prototyping and MVPs, mentor developers, define architecture, maintain CI/CD pipelines, and collaborate cross-functionally to deliver production-ready solutions.

Senior .NET full-stack developer responsible for custom application development, API integrations, database optimization, deployments, troubleshooting, performance, security, and production support using .NET/C#, ASP.NET Core, SQL, modern frontend frameworks, cloud, and CI/CD.

Lead full‑stack development of the imaging web platform: architect and build ASP.NET Core services and Vue frontends, design secure APIs integrating EMRs and AI, own testing, CI/CD, and Azure deployments, mentor engineers, and collaborate with product, design, and clinical teams to deliver performant, reliable screening experiences.

Lead design and delivery of full-stack imaging features, architect high-performance ASP.NET Core services, build Vue frontends, integrate APIs with EMRs and imaging partners, mentor engineers, enforce automated testing, CI/CD and observability, and drive technical roadmap in an Agile team.

As a Senior Fullstack Engineer, you'll develop end-to-end features for Cart & Checkout, collaborating with cross-functional teams. You will design full-stack solutions and ensure quality through documentation and monitoring, while also mentoring junior engineers and optimizing systems for performance.

Design, build, and test APIs and services for RoadieXD; develop internal and customer-facing React tools; partner with Product and Operations to deliver scalable, reliable features; influence architecture, write maintainable code, and improve system performance and developer experience.

Lead design and development of full‑stack banking and investment systems using TypeScript, React, Node and GraphQL. Collaborate with cross‑functional teams, architect scalable solutions, own the product lifecycle, ensure observability and performance, troubleshoot vendor integrations, and mentor teammates to deliver reliable financial products.

The role involves building and operating core services for authentication and data privacy, owning projects end-to-end, and enhancing system reliability.

As a Senior Backend Engineer, you will enhance Postscript's Fondue product by architecting scalable systems, driving decoupling, and implementing AI-first development practices while collaborating across teams.

Design, build, and ship agent-first AI products end-to-end. Implement production-ready agents using frontier models, ensure observability and quality via model-based evals and agent tracing, drive product definition with PMs/designers, and share agentic engineering practices to accelerate the team.

Lead full-stack development across Superset frontend and backend services. Design and ship end-to-end features, improve performance and scalability, own major technical initiatives, mentor engineers, set engineering standards, and collaborate with product, design, and the open-source community.

Build and maintain member- and host-facing features across web and mobile. Design scalable front-end architectures, ship React/Next.js and React Native/Expo apps, use AI tooling, own features end-to-end, collaborate with product and cross-functional teams, and contribute to testing and production readiness.

Build and ship full‑stack features for transportation management and other client products. Design and implement APIs and UIs, collaborate with product and design, own delivery, write modular testable code, troubleshoot and iterate quickly, and mentor peers.

Lead end-to-end design and implementation of a multi-tenant Azure SaaS security platform using Django REST and React/Next.js. Build scalable ingestion APIs, optimize PostgreSQL, integrate SIEM/EDR and AI model endpoints, implement security-by-design, maintain CI/CD pipelines, and mentor engineers while ensuring compliance and high performance.

Design, build, and own end-to-end features for AI-powered finance agents and agent orchestration. Implement integrations with accounting and payment platforms, create dashboards and reporting, ensure security and data integrity, make architectural choices, monitor production, and drive AI-assisted, agentic development workflows.

The Senior Software Engineer will design and build fullstack features using Go, React, and Ember, ensuring optimal customer experiences and system scalability while mentoring peers and driving projects.

As a Full-Stack Engineer, you'll design and build AI-powered applications, develop front-end interfaces, and scalable back-end services for enterprise users while collaborating with research and product teams.

The Senior Full-Stack Engineer will develop and ship features across frontend and backend systems, work with various frameworks and databases, write specifications, and improve development processes.

The Senior Software Engineer will work on full-stack deliverables, manage support tickets, and enhance the tech stack for improved efficiency, focusing on analytics and automation in OOH advertising.

Lead development of a passwordless, zero-trust platform using C++. Own complex, multithreaded systems, build CI/CD pipelines, write unit tests, perform Linux administration, apply image-processing with OpenCV, and use Python for scripting and integration. Collaborate in a fast-paced environment and mentor engineers.

As a Senior Full Stack Engineer, you'll design and build high-performance web applications, manage end-to-end solutions, and collaborate with teams to enhance user experiences.

Design, build, and scale data integrations for healthcare systems, collaborating with teams and enhancing functionality while ensuring security and quality.

Build and scale Mattermost's core web platform across Go backend and React/TypeScript frontend. Design and consume REST and WebSocket APIs, optimize PostgreSQL queries, maintain security/compliance for government and enterprise clients, own testing strategy and internal tooling, and integrate AI coding agents into daily development workflows. Contribute to open-source codebase.

Lead full-stack development across backend and frontend systems, implement and maintain features, fix bugs, collaborate with product and design, support client projects, and contribute to a distributed remote engineering team focused on high-impact startup missions.