Top Machine Learning Engineer Jobs in Chicago, IL

Build and deploy AI applications, agents, intelligent workflows, document-processing solutions, predictive analytics, and automation. The role spans AI use-case assessment, solution design, prototyping, evaluation, testing, production deployment, monitoring, governance, and responsible-AI controls. The engineer will integrate AI with enterprise systems, APIs, workflows, and data platforms while partnering with engineering, cybersecurity, governance, and mission teams in a federal environment.

Design, build, evaluate, and deploy AI agents and machine learning automation for engineering, product, delivery, and customer-facing workflows. Integrate AI into existing software, collaborate with technical and healthcare stakeholders, optimize systems for accuracy, latency, cost, and safety, and document development processes. The role emphasizes LLMs, agentic frameworks, production ML systems, human-in-the-loop safeguards, and healthcare-aware solutions.

Design, develop, and implement AI/ML models; analyze large datasets; integrate AI solutions into existing systems; apply MavLink for autonomous systems; collaborate across teams and improve ML development processes.

Design, build, and deploy production-grade ML systems for ICS/xOT cybersecurity, including threat detection, anomaly detection, NLP/LLM applications, and scalable data pipelines with observability and MLOps practices for cloud and on-prem environments.

As a Staff Machine Learning Engineer, you will design AI products on Edge devices, optimize ML model performance, and work with large-scale datasets, collaborating across teams to deliver impactful solutions.

Conduct machine learning research operations using existing infrastructure. Characterize neural network quality, failure modes, and edge cases; coordinate experiments with researchers; manage concurrent experiments and deadlines; review results; recommend theoretical or process improvements; and prepare technical reports communicating qualitative and quantitative findings.

Lead the design, development, deployment, and operation of machine learning systems at scale. Responsibilities include building and validating models, creating optimized data pipelines, automating testing and deployment, monitoring and retraining production models, designing cloud-based ML architectures, and applying responsible AI, governance, security, and explainability practices. The role also involves technical leadership, cross-functional Agile collaboration, and mentoring or leading teams developing production ML solutions.

Leads the design, development, deployment, and maintenance of production machine learning systems at scale. Responsibilities include developing and validating models, building optimized data pipelines, writing application code, automating testing and deployment, monitoring and retraining production models, designing cloud-based ML architectures, and applying responsible AI and governance practices. The role collaborates with Product, Data Science, and Agile engineering teams and may include people leadership.

Build and ship production LLM-powered agents, workflows, and integrations using platform templates, pipelines, and guardrails. Develop comprehensive evaluation suites, integrate business systems and data sources, instrument cost and quality telemetry, and collaborate with business users to iterate within defined scopes. Requires extensive software engineering experience, production LLM application expertise, strong Python and TypeScript skills, API craftsmanship, prompt and context engineering, and a commitment to guardrails and evaluation.

Build and deploy LLM-powered agents, workflows, and integrations using production templates, pipelines, and guardrails. Develop comprehensive evaluation suites, integrate with business systems and data sources, and instrument solutions for cost and quality telemetry. Collaborate with business users to iterate rapidly within defined scopes. The role requires strong Python and TypeScript skills, production LLM application experience, API development, prompt and context engineering, and retrieval expertise.

Build and deploy LLM-powered agents and workflows using production templates, pipelines, and guardrails. Develop comprehensive evaluations, integrate AI systems with business data sources, and instrument cost and quality telemetry. Collaborate with business users to rapidly iterate within defined scopes while maintaining production standards. The role requires extensive software engineering experience, production LLM application development, strong Python and TypeScript skills, API expertise, and retrieval or healthcare data experience as desirable qualifications.

Build and deploy LLM-powered agents and workflows using production templates, pipelines, and guardrails. Develop comprehensive evaluations, integrate with business systems and data sources, instrument cost and quality telemetry, and collaborate with business users to iterate within defined scopes. The role requires strong Python and TypeScript skills, production experience with agents, RAG, and tool use, as well as expertise in prompt and context engineering.

Develops AI/ML prototypes, APIs, microservices, integrations, and lightweight user interfaces for federal and DoD-aligned mission workflows. The role integrates and optimizes machine learning models for dashboards and applications, supports data ingestion and preprocessing, validates performance, and helps transition models into production. Collaboration with data scientists, architects, developers, PMO leadership, and cybersecurity teams is required. The position requires five years of relevant experience, a bachelor’s degree, ITIL v4 Foundation certification, and Public Trust or active Secret clearance.

Develop, deploy, and optimize scalable machine learning solutions, including predictive models, deep learning systems, data pipelines, and model-serving infrastructure. Monitor model performance, manage retraining and lifecycle processes, ensure quality and compliance, and support responsible AI practices. Collaborate with data scientists, engineers, product teams, and business stakeholders while researching emerging AI technologies and improving AI architectures.

Leads the architecture, development, deployment, and optimization of enterprise machine learning solutions. Responsibilities include designing scalable ML systems, developing predictive models, supporting MLOps and model lifecycle management, improving data quality and feature engineering, implementing governance and validation frameworks, and mentoring technical teams. The role also contributes to AI strategy, innovation initiatives, responsible AI practices, and organizational modernization.

Own the full machine learning lifecycle for search ranking and retrieval, including model training, deployment, serving, feature pipelines, evaluation frameworks, hybrid lexical-vector retrieval, large-scale embedding inference, query understanding, and permissions-aware multi-tenant search. Collaborate with infrastructure, AI, and backend teams to improve search relevance across ClickUp’s platform.

Own the architecture and hands-on implementation of production MLOps systems, scalable inference services, model deployment pipelines, monitoring, and governance. Integrate machine learning into pharmaceutical manufacturing, process control, automation, and scientific or clinical applications. Collaborate with chemical engineers, computational biologists, and platform teams while establishing enterprise CI/CD and MLOps standards. This is a hands-on senior role requiring hybrid onsite work in Indianapolis.

Design and productionize ML models and agentic systems for intraday financial alpha generation. Build data pipelines, experiment frameworks, and portfolio optimization methods. Collaborate with quants and engineers to move models from research to live trading environments.

Build and maintain Databricks ETL pipelines using Spark and Delta Lake, including transformations, quality checks, optimization, and documentation. Productionize propensity, ranking, and segmentation models through repeatable training, scoring, deployment, monitoring, versioning, and retraining workflows. Collaborate with data scientists on feature engineering and model evaluation, troubleshoot production issues, support A/B testing, and contribute to future GenAI initiatives.

Design, build, and deploy autonomous AI agents using LLMs and agent frameworks; integrate agents into e-commerce and supply chain systems; implement multi-agent orchestration, memory and tool integrations; fine-tune models and apply RL concepts; and build safety, monitoring, and MLOps pipelines.

Develop and own end-to-end machine learning models for Uber Freight’s marketplace, including cost prediction, booking probability, demand elasticity, pricing, matching, recommendations, and optimization. Collaborate with backend engineers to productionize models and ensure reliable performance. Apply predictive modeling, causal inference, constrained optimization, reinforcement learning, and marketplace design to solve business problems.

Set the technical direction for machine learning at Payabli by maturing production risk models and launching new models across the payments lifecycle. Establish experimentation, monitoring, drift detection, benchmarking, retraining, and incident-response foundations. Translate payments challenges into modeling opportunities, connect model performance to business outcomes, influence the ML roadmap, and mentor engineers while partnering with product, engineering, and risk operations.

Design, train, and productionize underwriting ML models for real-time transaction decisions. Build feature pipelines and training datasets, run experiments, integrate models into batch/real-time systems, and monitor data and model health while collaborating with cross-functional teams.

Design, productionize, and scale machine learning and optimization models, pipelines, libraries, and deployment platforms. Partner with data scientists, engineers, product managers, and business stakeholders to deliver ML capabilities, personalization systems, and reusable end-to-end workflows. Establish ML engineering best practices, troubleshoot data pipelines, mentor junior professionals, and help define BetterHelp’s ML platform strategy.

Build and maintain computer vision and machine learning pipelines for automated device inspection, grading, and quality assessment. Responsibilities include data preparation, feature engineering, model training and evaluation, production Python development, monitoring, annotation workflows, documentation, code reviews, and collaboration with product and operations teams. The role supports the full ML lifecycle and offers increasing ownership under senior engineering guidance.