Top Director of Operations Jobs in Chicago, IL

Directs utilization management operations, projects, business requirements, regulatory readiness, workflows, and program implementation. Monitors performance, drives evidence-based improvement, coordinates clinical and organizational stakeholders, supports legislative integration, and develops new business processes. Leads staff recruitment and development while ensuring compliance, communication, and execution across healthcare service areas including behavioral health, case management, pharmacy, and managed care.

Owns end-to-end operations for biomarker programs, including sample collection, chain of custody, lab processing, results, storage, quality, compliance, vendor management, and regulatory readiness. The role develops SOPs, KPIs, corrective action plans, and multi-year operating roadmaps; advises leadership on expansion and lab strategy; scales programs across U.S. sites; and eventually leads services coordinators. Requires extensive clinical lab, genetics, diagnostics, biobanking, or clinical research operations experience.

Leads clinical site management and oversight across the Americas, ensuring compliant, timely, and high-quality execution of clinical studies. Oversees monitoring plans, site performance, patient recruitment, CRO and vendor relationships, audit readiness, issue resolution, and corrective actions. Coordinates regional site management staff, supports feasibility and site selection, manages study budgets and timelines, and collaborates with clinical development, regulatory, and medical affairs stakeholders. The role requires extensive clinical operations, site monitoring, CRO management, ICH GCP, and inspection-readiness experience, with travel up to 50%.

Lead marketing operations for a B2B software company by managing lead, user, and account lifecycles; funnel definitions, scoring, routing, attribution, reporting, and forecasting. Build revenue-loss and budget-to-revenue models, guide global marketing planning, lead performance reviews, and use buyer intent, product engagement, AI, and automation to improve outreach and revenue growth. Own Salesforce and marketing automation systems while partnering with sales and revenue operations.

Leads SAP Application Management Services for utility clients across global delivery teams. Responsibilities include client governance, SLA and KPI ownership, incident escalation, service improvement, vendor management, financial performance, compliance, and operational excellence. The role manages executive stakeholder relationships, oversees SAP functional and technical teams, and drives delivery quality, profitability, and continuous improvement across complex utility environments.

Leads operational infrastructure for an asset-based lending portfolio, including servicing, collateral monitoring, risk controls, regulatory compliance, vendor oversight, technology initiatives, and team leadership. Develops operating strategies, manages systems and process improvements, oversees audits and regulatory examinations, establishes KPIs, supports financial analysis, and leads change initiatives. Partners with credit, risk, audit, finance, technology, and senior leadership teams to enable scalable and compliant portfolio growth.

Leads strategic sourcing, contracting, vendor governance, and commercial oversight for clinical operations, clinical trial supplies, and R&D procurement. Manages CROs, laboratories, eClinical providers, logistics partners, and other suppliers through competitive sourcing, negotiations, budgeting, performance management, risk mitigation, and continuous improvement. Partners cross-functionally with Clinical Operations, R&D, Finance, Legal, and Supply Chain to optimize costs, ensure compliance, and support global clinical study execution.

Own global sales strategy and operations for a rapidly scaling B2B travel technology company. Responsibilities include segmentation, account scoring, territory design, capacity modeling, goal setting, forecasting, pipeline reviews, QBRs, sales process design, and executive reporting. Lead AI strategy across prospecting, forecasting, deal execution, and coaching, while partnering with systems, finance, enablement, growth, and data teams. Build analyses directly and hire and manage a team of analysts and strategy partners.

Leads the Groups Contracts and Groups Bookings teams, owning group travel support operations from contract execution through booking and post-travel service. Oversees people development, BPO vendor performance, operational metrics, escalations, quality programs, process improvement, and cross-functional collaboration with Sales, Account Management, and Finance. Acts as a hands-on player/coach and contributes to broader Member Support strategy.

Leads global partner operations strategy and infrastructure across reseller, referral, delivery, technology, MSP, ISV, and cloud marketplace ecosystems. Builds scalable processes, dashboards, and reporting; integrates partner data with Salesforce, PRM, and BI systems; optimizes deal registration, attribution, compensation, onboarding, certification, and enablement workflows. Partners cross-functionally with Sales Operations, Alliances, Product, Finance, Marketing, IT, and executive leadership to improve partner performance and support growth.

Owns Temporal’s marketing operations function, including attribution, funnel measurement, lead scoring, routing, MarTech systems, campaign execution, and BDR pipeline processes. The role leads a marketing operations team and agency, migrates Marketo to an AI-native platform, builds agentic workflows, governs data privacy and system reliability, and partners across Marketing, Sales, Data, and Analytics to improve developer adoption, pipeline, and revenue.

Leads payer onboarding, transitions, ongoing payer operations, licensing, credentialing, audits, site inspections, and regulatory compliance for Babylist Health. Builds scalable processes, monitors payer performance, manages commercial and Medicaid operations, program-manages new business launches, and partners with billing, legal, product, contracting, and customer support. Manages and develops two direct reports while establishing the operational foundation for expanding clinical services.

Own Federal organization enablement, operating cadence, onboarding support, deal inspection, pipeline accountability, and strategic project execution. Partner cross-functionally with Sales, Product, Engineering, Delivery, Finance, and Operations to improve reporting, accountability, deal quality, and leadership capacity while creating practical structure in ambiguous, fast-moving environments.

Leads Temporal’s global Field Operations organization across Sales, Technical Services, and Partners. Owns operating cadence, forecasting, pipeline visibility, territory and quota planning, capacity modeling, partner operations, TAM analysis, performance insights, reporting standards, and process automation. Manages regional and functional operations leaders, partners with executive stakeholders, and establishes AI-native practices across the field organization.

Leads Engineering Operations by building the operating system connecting Product, Engineering, and Data strategy to measurable outcomes. Owns executive reporting, KPI and OKR definition, portfolio planning, software delivery reviews, capacity and headcount planning, risk and dependency tracking, and cross-functional decision-making. Partners with senior leaders across technology and business functions to improve delivery predictability, accountability, resource allocation, and organizational effectiveness.

Leads the strategy, governance, operations, and continuous improvement of a global, multi-brand web ecosystem. Oversees web development, UX/UI, CMS operations, publishing, infrastructure, agencies, and multidisciplinary teams. Develops technical roadmaps, operating models, governance frameworks, and scalable delivery processes while partnering with SEO, analytics, marketing, IT, and product teams. Directs migrations, platform consolidations, rebrands, and digital transformation initiatives, ensuring accessible, secure, high-performing websites that support engagement, conversion, and business growth.

Leads global marketing operations, technology, AI and automation, website operations, analytics, data governance, measurement, and digital experience strategy. Owns marketing technology investments, operating models, budgets, transformation initiatives, executive dashboards, attribution, and cross-functional alignment. Builds and manages a high-performing team while partnering with Marketing, Sales, Revenue Operations, Product, Technology, Data, Finance, and Legal.

Executive-level operator partnering with the CTO and CPO to drive technology and product planning, portfolio governance, resource allocation, executive cadence, strategic initiatives, and cross-functional alignment. The role improves decision velocity, manages risks and dependencies, operationalizes AI tooling, and connects technology investments to business outcomes across engineering, product, AI/ML, growth, and monetization teams.

Leads clinical operations analytics strategy, portfolio performance reporting, data governance, and Veeva Vault Clinical capabilities for global clinical trials. Develops KPIs, dashboards, scorecards, predictive analytics, and executive insights to improve study execution, site performance, resource planning, inspection readiness, and risk management. Oversees data standards, quality, technology enablement, process improvement, change management, and a team of analytics professionals while partnering across Clinical Operations, IT, CROs, and executive leadership.

The Director of Legal Operations will own Legal’s operating model, technology, AI strategy, budgeting, resourcing, vendor management, workflows, metrics, and change management. The role will modernize Legal through automation, secure AI deployment, standardized processes, knowledge management, demand management, and data-driven performance controls. This leader will partner with Engineering, Product, Security, Finance, and legal stakeholders to improve efficiency, manage risk, optimize costs, and enable attorneys to focus on strategic legal work.

Leads global pharmacovigilance operations and compliance across clinical and commercial products. Oversees case management, safety systems, vendors, budgets, inspections, regulatory reporting, quality, SOPs, training, signal support, and inspection readiness. Builds and develops global PV teams while advising senior leadership on operational risk, resourcing, compliance, and strategy. Requires extensive experience managing global PV operations, Health Authority inspections, and clinical and post-marketing safety activities.

Directs the company’s business systems, operations technology, automation standards, email deliverability, unified reporting, and AI enablement programs. Leads the Business Operations and AI Enablement teams, audits and improves Airtable and automation environments, manages vendors and IT helpdesk functions, partners with Engineering on data infrastructure, and drives cross-functional process improvements and technology adoption.

Owns the company’s business systems, automation standards, data layer, email deliverability, and AI enablement strategy. Leads Business Operations, including IT helpdesk, Airtable maintenance, vendor management, and process documentation. Audits and improves internal tools, reduces process inefficiencies, supports unified reporting across business systems, and manages cross-functional deployment of AI automations and agents.

Own and build the revenue operations function across Sales, Marketing, and Customer Success. Lead revenue strategy, GTM systems, lead routing, territory design, forecasting, reporting, deal desk, compensation planning, and cross-functional processes. Manage Salesforce, HubSpot, Gong, Intercom, warehouse integrations, APIs, Python, and AI tooling to improve data quality and operational efficiency. Partner with Finance, Analytics, and GTM leadership while managing a Revenue Operations Manager and directing GTM engineering resources.

Leads enterprise Finance transformation by defining the operating model and roadmap, modernizing processes and ERP capabilities, optimizing shared services, governing execution and value realization, and building change leadership and digital capabilities across Finance. Partners with executives across Accounting, Tax, Capital Markets, Technology, and business functions while managing risks, dependencies, resources, KPIs, and benefits.