Top Principal Data Scientist Jobs in Chicago, IL

Lead high-impact modeling initiatives using deep learning, LLMs, and traditional methods. Prototype, deploy, and monitor hybrid models on large insurance datasets, drive MLOps standards, and communicate results to nontechnical stakeholders to realize business impact.

Lead end-to-end data science for customer-embedded, production solutions: acquire and prepare messy datasets, develop and evaluate models tied to business outcomes, run experiments, deploy operational models at scale, coach cross-disciplinary teams, and drive strategy, ethics, and privacy discussions.

Lead end-to-end delivery of strategic data science and AI solutions for AI infrastructure. Work with telemetry and experimentation at fleet scale to build, deploy, and measure predictive and prescriptive models. Partner with stakeholders, present insights, enable adoption, and promote responsible AI. Collaborate closely with data engineers and infrastructure teams to productionize scalable ML solutions.

Lead data science engagements with customers to acquire, clean, analyze, and model data; develop scalable operational models and evaluation methods; coach engineers on best practices; drive solution strategy, ethics, and industry thought leadership; write extensible code and collaborate across teams to deliver cloud-based AI solutions.

Lead strategy and technical direction for generative and multimodal vision systems. Build end-to-end model workflows, improve realism, controllability, and robustness, drive evaluation and production-readiness, partner with engineering to deploy optimized inference, and mentor scientists while owning a major technical pillar from research to production.

Build and deploy machine learning and AI models for the Global Payments Network. Partner with cross-functional teams to design, train, evaluate, validate, and implement models using cloud and open-source tools. Drive innovation, translate technical work to business impact, and mentor talent.

Lead scientific design and data prototyping for Tempus' multimodal clinical-genomic platform. Perform data evaluation, write technical code (SQL, R, Python), design scalable data models (TDM), validate terabyte-scale datasets across oncology, neurology, and immunology, and translate findings into production-grade data products while advising clients and mentoring cross-functional teams.

The role involves partnering with data scientists and engineers to develop machine learning models, evaluate model risk in fraud detection, and translate complex data insights into business goals.

Lead end-to-end data science initiatives for commercial property or homeowners insurance: acquire and prepare data, build and validate predictive models, deploy and monitor production models, ensure governance and documentation, advise teams, and evaluate emerging ML/AI techniques to improve pricing, risk selection, and underwriting outcomes.

As a Senior Data Scientist at Yahoo Mail, you will enhance user growth strategies via product innovation, overseeing research projects and analytics.

Develop and validate SDTM and ADaM datasets using R per CDISC standards, support TLF generation in R or SAS, perform QC and reconcile data issues, collaborate with biostatistics and clinical teams, and contribute to automation and reproducible workflows for regulatory submissions.

Build and validate production-grade ML and AI systems across pricing, underwriting, claims, and portfolio management. Work with structured and unstructured data, LLMs and agentic workflows, extract information from documents, resolve entities, create feature pipelines and inference services, quantify uncertainty, monitor drift, and measure business impact in collaboration with engineers, actuaries, underwriters, and product teams.

Leads the design, development, deployment, and monitoring of advanced statistical and machine learning models for insurance pricing, underwriting, claims, fraud, retention, and growth. Advises executives and actuarial teams, establishes modeling and experimentation standards, ensures responsible and scalable productionization, and mentors data scientists. The role also advances MLOps, AI infrastructure, model lifecycle management, explainability, fairness, and data science strategy.

Lead end-to-end AI/ML initiatives to improve student retention, engagement, and enrollment. Architect and operate data pipelines, feature stores, and production ML systems; deploy, monitor, and automate models; run experimentation programing and measure business outcomes. Mentor team members and set technical standards across Product, Engineering, and CX.

Build and deploy AI/ML solutions from prototype through production for CMS, including generative AI, LLMs, RAG, intelligent classification, knowledge management, agentic frameworks, and enterprise integrations. Evaluate AI coding tools, establish AI/ML roadmaps, scale adoption, mentor data scientists, and translate technical concepts for stakeholders and leadership.

As a Senior Machine Learning Engineer, you'll build and deploy ML models for risk and fraud detection, leading technical efforts and collaborating cross-functionally.

The Senior Data Scientist will lead innovative data science efforts, leveraging advanced analytics, visualization, and insights from complex datasets to boost productivity.

Entefy seeks a Senior Data Scientist with a Master's or PhD in a relevant field, and 3+ years of experience. Responsibilities include delivering advanced analytics, leading teams, and extracting insights from datasets.