Top Senior Machine Learning Engineer Jobs in Chicago, IL

The Senior ML Engineer will develop and deploy full-stack AI solutions, manage LLM integration, and collaborate closely with defense clients to enhance real-world applications in secure environments.

The role involves designing and implementing advanced analytics solutions for healthcare payers, analyzing complex problems, mentoring juniors, and building client relationships.

As a Senior MLOps Engineer, you will manage production ML systems, define lifecycle strategies, optimize ML pipelines, and collaborate with cross-functional teams to enhance ML operations.

Design and maintain datasets, build and evaluate domain-specific ML and vision-language models for real-time privileged access threat detection; deploy and optimize Python/Docker inference services integrated with WebSocket/WebRTC and protocol-level interfaces; monitor and document production models.

The Senior Machine Learning Engineer leads technical direction for ML systems focused on personalization and ranking, overseeing architecture and implementation while mentoring team members.

Design, build, and own production ML and LLM-driven features (RAG, prompt engineering, fine-tuning, semantic search). Write maintainable code, create design docs, troubleshoot issues, collaborate with product/design, and participate in Agile development. Work with Python/Java/JavaScript, ML frameworks, and cloud/container technologies.

Design, train, and deploy scalable ML models (generative, classification, regression). Define feature roadmaps, collaborate with engineering to implement code and APIs, adapt ML methods for distributed/GPU environments, and create evaluation/annotation programs for fine-tuning and performance measurement.

Design, train, evaluate, and deploy predictive transportation and delivery ML models (primarily XGBoost). Perform EDA, feature engineering, experiment design, and statistical evaluation. Build production ML pipelines and MLOps practices on Google Vertex AI. Collaborate with data engineering and supply chain stakeholders to translate operational needs into scalable solutions.

Design, build, and own production ML and LLM-powered product features (chat, RAG, semantic search, data extraction). Write maintainable code and docs, debug issues, collaborate with product and design, follow Agile practices, and stay current on AI/ML methods.

Own and improve recommendation and search systems across feed, discovery, and search. Build retrieval and ranking (candidate generation, embeddings, two-tower models), run experiments, create user/content/session representations, and ship production ML systems with monitoring to improve retention, engagement, and content distribution.

The Machine Learning Engineer will build data-intensive products, deploy ML models, analyze datasets, and collaborate with product teams to enhance Nextdoor's platform.

The Senior Machine Learning Engineer will manage the full ML lifecycle, collaborating with teams to develop scalable systems that improve product decisions and empower monetization strategies.

As a Senior ML Engineer, you'll own ML-driven features from modeling to deployment, drive innovation in generative AI, and mentor junior members.

The role involves designing, training, and evaluating ML models, optimizing performance, and collaborating with teams to implement AI technologies in products.

Develop and deploy advanced ML solutions for OCR and NLP, optimizing models for performance and integrating them into production workflows while collaborating with cross-functional teams.

The Senior Machine Learning Engineer will utilize deep experience and insights to enhance communication and digital interactions through advanced machine learning tools and algorithms, focusing on unstructured data.

The Senior Machine Learning Engineer will design, train, and deploy ML models for optimizing revenue in advertising, taking ownership of product development and leading the ML discipline.

The role involves developing and optimizing machine learning systems for voice experiences, focusing on speech recognition and language understanding. Responsibilities include training models, ensuring performance metrics, and collaborating with cross-functional teams for successful deployment.

Design, fine-tune, evaluate, and deploy LLM-driven, user-facing browser features using RAG, embeddings, prompt engineering, and modern ML tooling. Lead end-to-end model lifecycle, run production experiments, collaborate with product and engineering, and document and review work with an emphasis on privacy, latency, and usability.

The Senior ML Engineer will automate component placement on PCBs, working on R&D and production using ML and optimization techniques.

As a Senior Machine Learning Engineer, develop LLM evaluation frameworks and agentic AI workflows to extract insights from conversations and optimize customer experiences.

Lead development of cutting-edge LLM and Agentic AI systems for Airbnb customer support, from research and prototyping to production deployment. Collaborate with product, design, and engineering to build scalable ML infrastructure, improve model performance, and implement evaluation, fine-tuning, and guardrails for chat and voice assistants.

The role involves owning and delivering AI-powered features for Calendly, collaborating with multiple teams, and applying machine learning solutions for product enhancement.

The role involves managing the ML lifecycle, developing scalable ML systems, and collaborating on AI-first product solutions focusing on Large Quantitative Models.

Lead development and maintenance of internal Python SDK frameworks and agentic workflows, build scalable FastAPI-based ML APIs, automate CI/CD with Jenkins and GitLab Runners, use Galileo for model evaluation and observability, and collaborate across teams to deliver production-grade autonomous systems.