Top Senior Machine Learning Jobs in Chicago, IL

Reposted 10 Days AgoSaved
Hybrid
Chicago, IL
179K-225K Annually
Senior level
179K-225K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Responsible for validating payment network models, including fraud and AML. Engage with stakeholders, improve model accuracy, and leverage innovative technology for data analysis.
Top Skills: AWSMachine LearningPythonRRelational DatabasesScalaStatistical Modeling
Reposted 4 Days AgoSaved
Easy Apply
Remote
Chicago, IL
Easy Apply
196K-247K Annually
Senior level
196K-247K Annually
Senior level
Artificial Intelligence • Fintech • Healthtech • Software
Lead the development of machine learning systems for Cedar Pay's Personalization Engine, manage ML engineers, and ensure ML model effectiveness.
Top Skills: Machine LearningPythonSQL
Reposted 5 Days AgoSaved
Easy Apply
Remote
Chicago, IL
Easy Apply
225K-245K Annually
Senior level
225K-245K Annually
Senior level
Healthtech • Software
The Staff Machine Learning Engineer will lead ML initiatives, develop ML systems, collaborate with cross-functional teams, and mentor junior engineers to optimize healthcare intake workflows using advanced machine learning techniques.
Top Skills: AWSCloud PlatformsDeep LearningMachine LearningPythonPyTorch
21 Days AgoSaved
Easy Apply
Hybrid
Chicago, IL
Easy Apply
96K-125K Annually
Senior level
96K-125K Annually
Senior level
Fintech • Information Technology • Machine Learning • Software • Analytics • Financial Services
Build, deploy, and monitor machine learning and pattern-recognition models to detect lending fraud. Analyze large transactional datasets with Python and SQL, partner with Fraud Operations to iterate on features and reduce false positives/negatives, communicate findings to stakeholders, apply AI in production, and mentor team members.
Top Skills: AIMachine LearningPythonSQL
Reposted 14 Hours AgoSaved
Hybrid
Chicago, IL
100K-160K Annually
Senior level
100K-160K Annually
Senior level
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Analytics • Biotech • Generative AI
The Machine Learning Scientist will develop AI frameworks for predictive modeling in oncology, collaborating with teams to enhance drug R&D efforts through advanced machine learning techniques and multimodal data integration.
Top Skills: AIGenerative AiLanggraphPython
Reposted 14 Days AgoSaved
Easy Apply
Remote
Chicago, IL
Easy Apply
200K-275K Annually
Senior level
200K-275K Annually
Senior level
Big Data • Fintech • Mobile • Payments • Financial Services
Lead a team of ML engineers to develop fraud detection models, defining strategies, driving model evolution, and ensuring effective integration with cross-functional teams.
Top Skills: Data PipelinesDeep LearningGradient-Boosted TreesMachine LearningRepresentation LearningScalable SystemsTransformer-Based Models
Reposted YesterdaySaved
Hybrid
Chicago, IL
Senior level
Senior level
Financial Services
Design, develop, and deploy scalable AI/ML solutions and agentic LLM systems for payments. Build data pipelines, perform analysis, partner with Product, Technology, Risk and Compliance, track model performance and regulatory documentation, and translate model outcomes into business impact.
Top Skills: AWSComputer VisionDspyGenerative AiJupyter Notebook/LabLangchainLanggraphLarge Language Models (Llm)Model Context Protocol (Mcp)NlpNumpyPandasPysparkPythonPyTorchScikit-LearnShell ScriptingSQLTensorFlow
Reposted 2 Days AgoSaved
In-Office or Remote
Chicago, IL
113K-193K Annually
Senior level
113K-193K Annually
Senior level
Artificial Intelligence • Big Data • Healthtech • Information Technology • Machine Learning • Software • Analytics
Lead design and delivery of scalable Amazon Connect voice and chat solutions. Build Lambda-based integrations, integrate Lex bots and external systems, optimize routing/queues, ensure high availability and monitoring, lead production support, RCA, and continuous improvement for contact center platforms.
Top Skills: Amazon Api GatewayAmazon ConnectAmazon LexAPIsAws LambdaIvrNode.jsTypescript
Reposted 2 Days AgoSaved
Hybrid
Chicago, IL
101K-205K Annually
Senior level
101K-205K Annually
Senior level
Fintech • Machine Learning • Payments • Software • Financial Services
Lead product efforts for machine learning-driven marketing and acquisition products. Collaborate with data scientists, engineers, and designers to define acceptance criteria, break down epics into MVP features and user stories, prioritize roadmaps, manage agile delivery, and drive stakeholder alignment to build scalable ML product platforms.
Reposted 12 Hours AgoSaved
In-Office
Chicago, IL
102K-222K Annually
Senior level
102K-222K Annually
Senior level
Fitness • Healthtech • Retail • Pharmaceutical
Lead end-to-end analytics and ML initiatives for PBM member engagement: build, deploy, and monitor large-scale ML/DL models; perform EDA and data quality assessments on prescription claims; collaborate with engineering and stakeholders to create feature stores and MLOps pipelines; communicate results to business leaders; mentor peers and interns.
Top Skills: AWSAzureDeep LearningGCPGitLarge Language ModelsMachine LearningMlopsPrompt EngineeringPythonRetrieval-Augmented Generation (Rag)SQL
Reposted 2 Days AgoSaved
In-Office
Chicago, IL
116K-193K Annually
Senior level
116K-193K Annually
Senior level
Automotive • Insurance
Lead a small team to design, build, deploy, and monitor ML/AI solutions for Claims (fraud, triage, severity, litigation, subrogation). Manage projects, collaborate with engineering and IT, follow model governance, and mentor staff.
Top Skills: Agentic AiAIGitMachine LearningModel Lifecycle ManagementPythonSQL
Reposted 3 Days AgoSaved
Hybrid
Chicago, IL
120K-140K Annually
Senior level
120K-140K Annually
Senior level
Hardware • Security • Software • Cybersecurity
Lead the AI & Analytics stream to design, build, and deploy predictive and prescriptive ML models, integrate analytics into enterprise platforms (Salesforce, ServiceNow), automate root-cause and log analysis, translate stakeholder needs into production solutions, and manage analytics projects end-to-end while communicating results to technical and executive partners.
Top Skills: Machine LearningPythonRSalesforceServicenowSystem Log Analytics
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Reposted 2 Days AgoSaved
Remote
Chicago, IL
190K-190K Annually
Senior level
190K-190K Annually
Senior level
Security • Cybersecurity
Design, build, and deploy production-grade ML systems for ICS/xOT cybersecurity, including threat detection, anomaly detection, NLP/LLM applications, and scalable data pipelines with observability and MLOps practices for cloud and on-prem environments.
Top Skills: Ci/CdDockerGoHuggingfaceJavaKubernetesLlmsMessage QueuingMlopsModel VersioningNlpPipeline OrchestrationPythonPyTorchRetrieval-Augmented Generation (Rag)RustScikit-LearnSQLStream ProcessingTensorFlow
Reposted 7 Days AgoSaved
In-Office
Chicago, IL
112K-131K Annually
Senior level
112K-131K Annually
Senior level
Fintech
Design and maintain data models and pipelines for mortgage and lending platforms. Develop ML/AI, predictive and prescriptive analytics, and LLM/Generative AI solutions. Collaborate with engineering and business stakeholders to build scalable cloud and data warehouse solutions, ensure data quality and governance, and deliver dashboards and executive reporting.
Top Skills: AIAws Ai ServicesAzure AiAzure OpenaiCloudData WarehouseETLGenerative AiLlm OptimizationLlmsMachine LearningMlopsPrompt EngineeringRetrieval-Augmented Generation (Rag)
3 Days AgoSaved
Remote or Hybrid
Chicago, IL
140K-215K Annually
Senior level
140K-215K Annually
Senior level
Cloud • Computer Vision • Information Technology • Sales • Security • Cybersecurity
Design, build, and support high-throughput, low-latency LLM inference and data pipelines; collaborate with data scientists to post-train and evaluate models; implement scalable, production-ready systems with strong testing, monitoring, and performance focus; mentor engineers and iterate on architecture, reliability, and user-facing AI applications.
Top Skills: AnsibleAWSCassandraChefDockerElasticsearchGCPGpuGpu-ClustersJvmKafkaKubernetesMaasPythonSparkTerraform
Reposted 3 Days AgoSaved
Easy Apply
Remote or Hybrid
Chicago, IL
Easy Apply
179K-319K Annually
Senior level
179K-319K Annually
Senior level
Artificial Intelligence • Cloud • Computer Vision • Hardware • Internet of Things • Software
As a Staff Machine Learning Engineer, you will design AI products on Edge devices, optimize ML model performance, and work with large-scale datasets, collaborating across teams to deliver impactful solutions.
Top Skills: C++PythonRayRustSpark
Reposted 4 Days AgoSaved
Remote
Chicago, IL
175K-230K Annually
Senior level
175K-230K Annually
Senior level
Artificial Intelligence • Healthtech • Machine Learning • Natural Language Processing • Software • Generative AI
The Sr. Machine Learning Engineer will develop and deploy ML solutions for healthcare, manage data pipelines, and work with large datasets to enhance healthcare delivery.
Top Skills: AWSC++KubernetesPythonPyTorchScikit-LearnSparkTensorFlow
Reposted 4 Days AgoSaved
Remote
Chicago, IL
200K-240K Annually
Senior level
200K-240K Annually
Senior level
Fintech • Information Technology • Software
As a Staff Applied ML Scientist, you will develop and maintain fraud detection models, conduct research on fraud types, and collaborate across teams to drive product development and real-time decision-making.
Top Skills: AWSPostgresPython 3
Reposted 4 Days AgoSaved
Remote
Chicago, IL
200K-240K Annually
Senior level
200K-240K Annually
Senior level
Fintech • Information Technology • Software
As a Senior Applied ML Scientist, you'll develop fraud detection models, research new fraud types, and write production code while collaborating across teams to enhance SentiLink's identity verification solutions.
Top Skills: Aws Ec2Aws RdsAws RedshiftAws S3PostgresPython 3
Reposted 9 Hours AgoSaved
Remote
Chicago, IL
400K-640K Annually
Senior level
400K-640K Annually
Senior level
News + Entertainment
Lead integration of state-of-the-art AI/ML into Netflixs content platform and publishing tools. Build roadmaps, incubate ML systems from idea to production, partner with researchers and engineers, automate promotional asset creation, optimize distribution and localization, and measure impact with data-driven evaluation.
Top Skills: AICatalog/Taxonomy ToolsContent Management SystemsData LabelingMachine LearningMedia Supply ChainsMl LifecycleModel Evaluation
Reposted 10 Days AgoSaved
In-Office or Remote
Chicago, IL
Senior level
Senior level
Big Data • Food • Mobile • Payments
The Senior Machine Learning Engineer leads technical direction for ML systems focused on personalization and ranking, overseeing architecture and implementation while mentoring team members.
Top Skills: Ai ToolsData PipelinesDistributed SystemsLlmsMachine LearningMl Infrastructure
Reposted YesterdaySaved
Remote
Chicago, IL
Senior level
Senior level
Healthtech
Build, ship, and own end-to-end ML models for vendor matching, order routing, and supply-chain optimization. Partner with data engineering to productionize models, quantify impact, document work, and implement decision logic components toward agentic AI in a fast-moving healthcare startup environment.
Top Skills: Agentic AiCausal InferenceGitMachine LearningOperations ResearchPythonReinforcement LearningSQL
3 Days AgoSaved
Remote
Chicago, IL
179K-210K Annually
Senior level
179K-210K Annually
Senior level
Real Estate • Travel • PropTech
Lead causal inference and measurement efforts for payments, build and evaluate ML/AI and LLM-based models, optimize fraud mitigation and loss strategies, simulate interventions, and communicate findings to stakeholders to drive product and risk decisions.
Top Skills: LlmMachine LearningPythonRSQL
Reposted 4 Days AgoSaved
Remote
Chicago, IL
250K-300K Annually
Senior level
250K-300K Annually
Senior level
Automotive • Insurance • Machine Learning • Mobile • Software
Lead a multidisciplinary team to design, deploy, and optimize ML-driven bidding systems and measurement for a nine-figure marketing budget. Drive experimentation, partner strategy, media-mix optimization, and end-to-end measurement while aligning Marketing, Analytics, Engineering, and Product to improve marketing ROI and scale performance.
Top Skills: AWSMachine LearningMobile Telematics
Reposted 10 Days AgoSaved
Easy Apply
Remote or Hybrid
Chicago, IL
Easy Apply
134K-181K Annually
Senior level
134K-181K Annually
Senior level
Automotive • Big Data • Insurance • Software • Transportation
Design, develop, and deploy machine learning models and pipelines to optimize operations. Lead full ML project lifecycle, ensure model evaluation/monitoring, collaborate cross-functionally, mentor junior engineers, and drive continuous improvement in ML applications and processes.
Top Skills: AirflowAws EcrAws S3Aws SagemakerCi/CdDvcNumpyPandasPythonRestful ApisScikit-LearnSQL
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