Top Senior Machine Learning Jobs in Chicago, IL

Design, develop, and deploy machine learning models and pipelines to optimize operations. Lead full ML project lifecycle, ensure model evaluation/monitoring, collaborate cross-functionally, mentor junior engineers, and drive continuous improvement in ML applications and processes.

Owns end-to-end development of datasets, reinforcement learning environments, and evaluations for coding agents and software engineering models. Leads engineers, researchers, QA professionals, and data creators; establishes quality processes, pipelines, validation, and review workflows. Collaborates directly with frontier AI labs, fine-tunes models, builds benchmarks, develops automation and internal tools, and supports customer-facing enablement. The role combines hands-on technical leadership, engineering management, operational execution, research, and industry thought leadership.

Leads and manages an applied machine learning team developing fraud detection and identity verification models. Responsibilities include people management, coaching, code review, production ML systems, model lifecycle ownership, experimentation, deployment, monitoring, fraud research, cross-functional prioritization, and communicating results. The role remains hands-on while partnering with Product, Engineering, Risk, and leadership to drive measurable business impact and shape future product strategy using machine learning and AI.

Builds and maintains full-stack software products and backend services with a strong Java and Spring Boot focus. Develops APIs, UI, infrastructure, CI/CD pipelines, and production machine learning or GenAI systems. Practices test-driven development, supports incident response, addresses security and compliance findings, performs root-cause analysis, and coaches junior engineers. Collaborates on architecture, participates in Agile ceremonies, and improves observability, deployment readiness, and product quality.

Design and deploy machine learning models for financial document processing, optimize large language models, collaborate with cross-functional teams, and guide junior peers in a fast-paced environment.

Lead end-to-end ML systems for identity verification, including document authenticity, face match, liveness and deepfake detection. Build GNN-based identity graphs, behavioral/device-intelligence models, vendor benchmarking/evaluation, and production enforcement. Mentor engineers and align ML architecture with Product, Compliance, Risk, and Security stakeholders.

Designs, evaluates, and improves ranking and recommendation systems through experimentation, feature engineering, and production machine learning. Builds reliable data and feature pipelines, incorporates multimodal signals, manages uncertainty, calibration, and model drift, and monitors system performance. Partners cross-functionally with Engineering, Product, Business, and Analytics to deliver scalable, latency-sensitive solutions with measurable business impact.

The Senior Machine Learning Engineer will develop core ML models, manage data pipelines, and collaborate with stakeholders to deliver scalable ML solutions.

Design, build, and deploy production-grade ML systems for ICS/xOT cybersecurity, including threat detection, anomaly detection, NLP/LLM applications, and scalable data pipelines with observability and MLOps practices for cloud and on-prem environments.

The Senior Machine Learning Researcher will design experiments, research new algorithms, and collaborate on deploying models for computer vision and robotics applications.

As a Staff Machine Learning Engineer, you will design AI products on Edge devices, optimize ML model performance, and work with large-scale datasets, collaborating across teams to deliver impactful solutions.

Designs and operates production multi-agent AI systems, LLM workflows, scoring and optimization algorithms, and closed-loop autonomous processes. Responsibilities include AI model evaluation, production monitoring, governance, third-party AI integration, federated data retrieval, and identifying patentable inventions. The role requires deep machine learning expertise, algorithm development, and deployment experience across complex operational environments.

The Sr. Machine Learning Engineer will develop and deploy ML solutions for healthcare, manage data pipelines, and work with large datasets to enhance healthcare delivery.

As a Staff Applied ML Scientist, you will develop and maintain fraud detection models, conduct research on fraud types, and collaborate across teams to drive product development and real-time decision-making.

As a Senior Applied ML Scientist, you'll develop fraud detection models, research new fraud types, and write production code while collaborating across teams to enhance SentiLink's identity verification solutions.

Leads architecture and development of production-grade mapping and localization ML systems for autonomous vehicles. Designs neural models for detection, segmentation, tracking, depth estimation, 3D reconstruction, and semantic mapping; owns data strategy, evaluation, deployment, and fleet validation. Mentors engineers, drives technical roadmaps, collaborates cross-functionally, and advances vectorized HD mapping, foundation models, and real-time optimization.

Develop and optimize large-scale advertising ranking models for CTR and CVR prediction, calibration, user representations, and sequence modeling. Own machine learning systems end to end, including data pipelines, feature engineering, training, evaluation, deployment, and maintenance. Collaborate with platform, product, data science, and engineering teams to run experiments and improve advertiser outcomes, revenue, and user relevance. Apply deep learning and recommendation techniques within production latency, reliability, and cost constraints.

Design, productionize, and deploy machine learning forecasting models for ad inventory and campaign performance in low-latency, real-time advertising environments. Build scalable simulation, budgeting, and pacing systems; collaborate with cross-functional teams to deploy models at scale and optimize ad monetization.

Conduct machine learning research operations using existing infrastructure. Characterize neural network quality, failure modes, and edge cases; coordinate experiments with researchers; manage concurrent experiments and deadlines; review results; recommend theoretical or process improvements; and prepare technical reports communicating qualitative and quantitative findings.

Develops AI/ML prototypes, APIs, microservices, integrations, and lightweight user interfaces for federal and DoD-aligned mission workflows. The role integrates and optimizes machine learning models for dashboards and applications, supports data ingestion and preprocessing, validates performance, and helps transition models into production. Collaboration with data scientists, architects, developers, PMO leadership, and cybersecurity teams is required. The position requires five years of relevant experience, a bachelor’s degree, ITIL v4 Foundation certification, and Public Trust or active Secret clearance.

Leads the architecture, development, deployment, and optimization of enterprise machine learning solutions. Responsibilities include designing scalable ML systems, developing predictive models, supporting MLOps and model lifecycle management, improving data quality and feature engineering, implementing governance and validation frameworks, and mentoring technical teams. The role also contributes to AI strategy, innovation initiatives, responsible AI practices, and organizational modernization.

Build, ship, and own end-to-end ML models for vendor matching, order routing, and supply-chain optimization. Partner with data engineering to productionize models, quantify impact, document work, and implement decision logic components toward agentic AI in a fast-moving healthcare startup environment.

Lead causal inference and measurement efforts for payments, build and evaluate ML/AI and LLM-based models, optimize fraud mitigation and loss strategies, simulate interventions, and communicate findings to stakeholders to drive product and risk decisions.

Productionize and optimize ML systems for AI reasoning over structured data. Responsibilities include improving training and inference performance, porting workloads from CPU to GPU, building training and deployment infrastructure, developing experimentation and observability tools, and implementing new model architectures and fine-tuning methods using Python and PyTorch. The role requires strong ML research, systems engineering, software architecture, optimization, and experimental design skills.

Lead end-to-end deployments of AI for hotel revenue teams: integrate PMS/CRS/RMS, ship ML/optimization models and agentic workflows, validate recommendations with revenue managers, define metrics, drive adoption, and hire/mentor the forward deployed engineering team.